Epilepsy & cardiac disorders eg, conduction disturbances, angina pectoris & recent MI; hypotension, DM, psychoses & history of bipolar disorder. Discontinue treatment if fever, sore throat, stomatitis, other signs of infection & jaundice develops. Perform blood count. Micturition disturbances, angle-closure glaucoma & increased IOP. Potential risk of w/drawal & suicidal tendencies. May impair ability to drive or operate machinery. Renal or hepatic impairment. Elderly.